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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment Adopted according to OECD SIDS or other official EU regulation procedures (public available peer reviewed source).

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1977
Reference Type:
secondary source
Title:
SIDS Category of Alkyl sulfates, Alkane sulfonates and Alpha-olefin sulfonates
Author:
OECD
Year:
2007
Bibliographic source:
UNEP Publications

Materials and methods

Principles of method if other than guideline:
Method: other: Unilever in-house protocol
GLP compliance:
no
Type of study:
guinea pig maximisation test

Test material

Constituent 1
Reference substance name:
85586-07-8 (purity 29.9%)
IUPAC Name:
85586-07-8 (purity 29.9%)
Details on test material:
- Name of test material (as cited in study report): Trade name
- Physical state: No data
- Analytical purity: 29.9% a.i.
- Lot/batch No.: No data
- Storage condition of test material: No data

In vivo test system

Test animals

Species:
guinea pig

Study design: in vivo (non-LLNA)

Induction
Vehicle:
other: intradermal injection: saline; topical application: distilled water
Challenge
Vehicle:
other: intradermal injection: saline; topical application: distilled water
No. of animals per dose:
10
Details on study design:
1st application: Induction 0.08% intracutaneous
2nd application: Induction 0.5% occlusive epicutaneous
3rd application: Challenge 0.1% occlusive epicutaneous

Results and discussion

Any other information on results incl. tables

0/10 guinea pigs sensitised after 2 challenges

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU