2,2'-dimorpholinyldiethyl ether

Dissociation constant

Link to relevant study record(s)

Reference

Endpoint:

dissociation constant

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2011-07-11

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

Well performed GLP study in accordance with OECD Guideline 112.

Qualifier:

according to guideline

Guideline:

OECD Guideline 112 (Dissociation Constants in Water)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: PFW100113
- Analytical purity: 99.3% (by GC)

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: the sample is stored in cool, well-ventilated storage area prior to testing.

OTHER SPECIFICS:
- Name of test material (as cited in study report): Jeffcat DMDEE
- Physical state: Liquid

Dissociating properties:

yes

No.:

#1

pKa:

6.8

Temp.:

20 °C

Remarks on result:

other: No details on temperature are provided, however ambient temperature is anticipated

Conclusions:

The dissociation constant of the substance was determined to be 6.8 ± 0.5.

Description of key information

The dissociation constant of the test substance was determined to be 6.8 at ambient temperature following a GLP study conducted in accordance with guideline OECD 112 using the titration method (Younis, 2011).

Key value for chemical safety assessment

pKa at 20°C:

6.8

Additional information

Although the temperature was not reported it was assumed that the study was conducted at ambient temperature.