Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 202-943-5 | CAS number: 101-43-9
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyclohexyl methacrylate
- EC Number:
- 202-943-5
- EC Name:
- Cyclohexyl methacrylate
- Cas Number:
- 101-43-9
- Molecular formula:
- C10H16O2
- IUPAC Name:
- cyclohexyl 2-methylprop-2-enoate
Constituent 1
- Specific details on test material used for the study:
- - Lot/batch No.: CHMA Verkaufstank 14 v.=1092011
- Radiolabelling:
- no
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Methacrylic acid is formed when cyclohexyl methacrylate is incubated in rat liver 9 mix or rat plasma.
Any other information on results incl. tables
Incubation in rat liver S9 mix
CHMA completely decreased within the first 10 min in the organic phase. This result correlated with the development of methacrylic acid in the aqueous phase within the same time frame.
Incubation in rat plasma
After 30 minutes a 80 % reduction of CHMA is observed. At the same time the methacrylic acid increased linearly by 20 %.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
