Registration Dossier
Registration Dossier
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EC number: 500-097-4 | CAS number: 37353-75-6 1 - 4.5 moles propoxylated
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Expert assessment
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Estimation based on testing performed on this class of substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
- Objective of study:
- other: ADME assessment
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Assessment based on data presented in registration dossier. No further animal testing is justified
- GLP compliance:
- no
Test material
- Reference substance name:
- 4,4'-Isopropylidenediphenol, propoxylated
- EC Number:
- 500-097-4
- EC Name:
- 4,4'-Isopropylidenediphenol, propoxylated
- Cas Number:
- 37353-75-6
- Molecular formula:
- The substance is a UVCB and contains a series of homologues that have the general molecular formula C15H16O2.(C3H6O)n, where 2 ≤ n ≤ 10 (average degree of propoxylation: => 1 ; < 4.5 )
- IUPAC Name:
- 4,4-'isopropylidene, propoxylated (1 - 4.5 moles propoxylated)
Constituent 1
- Radiolabelling:
- no
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Type:
- distribution
- Type:
- metabolism
- Type:
- excretion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Absorption by oral route as transient systemic effects seen in test animals
- Details on distribution in tissues:
- Effects indicate exposure to liver and kidneys
- Details on excretion:
- No firm evidence, but kidney response seen in highest treatment group
Metabolite characterisation studies
- Metabolites identified:
- no
Any other information on results incl. tables
Substance is known to be readily biodegradable, suggesting that metabolism to CO2 will occur in biological systems
Applicant's summary and conclusion
- Conclusions:
- There appears to be limited risk of bioaccumulation
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