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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Dissociation constant

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Administrative data

Link to relevant study record(s)

Description of key information

Attempts to determine the pKa experimentally have failed due to lack of detection sensitivity (see supporting study). Consequently, a calculated value for pKa of homosalate is provided in the supporting study. This is in line with expectations as the reference substance homosalate can be considered as a phenol substituted by an ester function in ortho-position. Although the ester function is slightly electron pulling, the effect on acidity of phenol is low and therefore the pKa of homosalate is expected to be slightly lower than the pKa of phenol (pKa 9.9 according to literature). 

Key value for chemical safety assessment

pKa at 20°C:

Additional information