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EC number: 212-836-5 | CAS number: 873-32-5
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species, other
- Remarks:
- calculation
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- As no experimental data regarding the bioaccumulation potential of 2-chlorobenzonitrile are available, the BCF was calculated using several estimation methods (BCFWIN v2.15, BCF-QSAR according to the TGD, EU 2003, and Solaris v4.67). The calculations were based on a measiured log Kow of 2.2.
- GLP compliance:
- not specified
- Radiolabelling:
- no
- Vehicle:
- no
- Test type:
- other: estimated by calculation
- Details on estimation of bioconcentration:
- BASIS INFORMATION
- Measured/calculated logPow: 2.2
BASIS FOR CALCULATION OF BCF
- Estimation software: BCFWIN v2.15, BCF-QSAR according to the TGD, EU 2003, and Solaris v4.67
- Result based on measured log Pow of:
* BCFWIN v2.15: BCF = 9.9
* BCF-QSAR: BCF = 14.8
* Solaris v4.67: BCF = 21.3 (pH 1-10) - Key result
- Type:
- BCF
- Value:
- >= 9.9 - <= 21.3 dimensionless
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The calculated BCF values range between 9.9 and 21.3 and therefore indicate only a low bioaccumulation potential of 2-chlorobenzonitrile.
- Executive summary:
As no experimental data regarding the bioaccumulation potential of 2-chlorobenzonitrile are available, the BCF was calculated using several estimation methods (BCFWIN v2.15, BCF-QSAR according to the TGD, EU 2003, and Solaris v4.67).
The calculations were based on a measured log Kow of 2.2.
The calculated BCF values using diifferent estimation methods range between 9.9 and 21.3. These BCF values indicate that 2-chlorobenzonitrile has only a low bioaccumulation potential.
Reference
Description of key information
2-chlorobenzonitrile has a low potential for bioaccumulation.
Key value for chemical safety assessment
- BCF (aquatic species):
- 21.3 dimensionless
Additional information
As no experimental data regarding the bioaccumulation potential of 2-chlorobenzonitrile are available, the BCF was calculated using several estimation methods (BCFWIN v2.15, BCF-QSAR according to the TGD, EU 2003, and Solaris v4.67).
The calculations were based on a measured log Kow of 2.2.
The calculated BCF values using diifferent estimation methods range between 9.9 and 21.3. These BCF values indicate that 2-chlorobenzonitrile has probably only a low bioaccumulation potential.
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