Registration Dossier
Registration Dossier
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EC number: 200-658-0 | CAS number: 67-52-7
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Remarks:
- Two trophic levels and taxa were well investigated and covered. An additional study on aquatic invertebrates is scientifically not necessary and a QSAR prediction model using ECOSAR version 1.11 was applied instead
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction
ECOSAR class specific estimation (carbonyl ureas)
Data source
Reference
- Title:
- ECOSAR Version 1.11
- Author:
- ECOSAR v1.11, United States Environmental Protection Agency, Washington, DC, USA.
- Year:
- 2 013
- Bibliographic source:
- ECOSAR v1.11, United States Environmental Protection Agency, Washington, DC, USA.
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: ECHA Guidance on information requirements and chemical safety assessment, Chapter R.6: QSARs and grouping of chemicals
- Qualifier:
- according to guideline
- Guideline:
- other: ECHA Practical Guide, How to reoart (Q)SARs
- Version / remarks:
- version 3.1, July 2016
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Series on Testing and Assessment, No. 102
- GLP compliance:
- no
Test material
- Reference substance name:
- Barbituric acid
- EC Number:
- 200-658-0
- EC Name:
- Barbituric acid
- Cas Number:
- 67-52-7
- Molecular formula:
- C4H4N2O3
- IUPAC Name:
- pyrimidine-2,4,6(1H,3H,5H)-trione
- Details on test material:
- Target substance:
barbituric acid (CAS 67-52-7)
SMILES: C1(=O)CC(=O)NC(=O)N1
Catergory members used for read-across:
tetraacetylethylenediamine (CAS *0-09-6)
n-methyl-2-pyrrolidone (CAS 872-50-4)
2-piperidinone (CAS 675-20-7)
acetyl caprolactam (CAS 1888-91-1)
hexahydro-2h-azepin-2-one (CAS 105-60-2)
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not required
Study design
- Test type:
- not specified
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 12 964 mg/L
Applicant's summary and conclusion
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