Barbituric acid

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

OECD 105

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2019

Report date:

2019

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

Barbituric acid

EC Number:

200-658-0

EC Name:

Barbituric acid

Cas Number:

67-52-7

Molecular formula:

C4H4N2O3

IUPAC Name:

pyrimidine-2,4,6(1H,3H,5H)-trione

Results and discussion

Water solubility

Key result

Water solubility:

10.4 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

2.5

Remarks on result:

other: mean of 3 measurements

Any other information on results incl. tables

Table 1: results of preliminary test

water for 0.1 g test item [mL]	0.1	0.5	1	2	10	100	150
approximate solubility [g/L]	> 1000	200 -1000	100 - 200	50 - 100	10 - 50	1 – 10	< 1
visual evaluation	not soluble	not soluble	not soluble	not soluble	not soluble	soluble	soluble

Table 2: results of flask method

Flask no	Equilibration time at 20 °C [h]	Test substance content [g/L]
1	24	10.4
2	48	10.3
3	72	10.3
mean		10.4