Barbituric acid

Partition coefficient

Administrative data

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

OECD 107

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2019

Report date:

2019

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

Type of method:

shake-flask method to: flask method

Partition coefficient type:

octanol-water

Test material

Test material information

Constituent 1

Reference substance name:

Barbituric acid

EC Number:

200-658-0

EC Name:

Barbituric acid

Cas Number:

67-52-7

Molecular formula:

C4H4N2O3

IUPAC Name:

pyrimidine-2,4,6(1H,3H,5H)-trione

Study design

Analytical method:

photometric method

Results and discussion

Partition coefficient

Key result

Type:

log Pow

Partition coefficient:

-2.39

Temp.:

23 °C

pH:

ca. 3.2

Remarks on result:

other: mean of 6 measurements

Any other information on results incl. tables

Table 1: Results

no.	stock solution [mL]	n-octanol [mL]	conc. in n-octanol phase [mg/L]	conc. in water phase [mg/L]	log pow
A1	5	10	3.7	1023.4	- 2.44
A2	5	10	3.9	1022.0	- 2.42
B1	10	10	3.8	1044.4	- 2.44
B2	10	10	4.8	1035.1	- 2.34
C1	20	10	4.6	1048.3	- 2.36
C2	20	10	5.0	1058.0	- 2.32
mean	-	-	-	-	- 2.39

Stock solution: 986 mg/L

The recovery rate of the test substance was between 104 % and 108 %.