Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-359-4 | CAS number: 3445-11-2
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-(2-hydroxyethyl)pyrrolidin-2-one
- EC Number:
- 222-359-4
- EC Name:
- 1-(2-hydroxyethyl)pyrrolidin-2-one
- Cas Number:
- 3445-11-2
- Molecular formula:
- C6H11NO2
- IUPAC Name:
- 1-(2-hydroxyethyl)pyrrolidin-2-one
- Details on test material:
- Name of the test substance used in the study report: 1-(2-hydroxyethyl)pyrrolidone-2
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Kisslegg
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- The test substance was given as a 2, 20 or 30% (v/v) aqueous solution
- Doses:
- 200, 1600, 3200, 4000, 5000, 5600, 6400 mm3/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 6 000 other: mm3/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 6 900 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: calculated from original value
- Mortality:
- 200, 1600, 3200 and 4000 mm3/kg: no mortalities
5000 mm3/kg: 2/5 female animals after 14 days
5600 mm3/kg: 1/5 males after 14 days
6400 mm3/kg: 3/5 males and 4/5 females after 14 days. - Clinical signs:
- Dyspnea, abdominal and lateral positions and convulsions.
- Body weight:
- No datails given in study report.
- Gross pathology:
- No abnormalities detected.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
