Registration Dossier
Registration Dossier
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EC number: 203-558-5 | CAS number: 108-18-9
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- The physiological response of animals to respiratory exposure to the vapors of diisopropylamine
- Author:
- Treon JF, Sigmon H, Kitzmiller KV and Heyroth FF
- Year:
- 1 949
- Bibliographic source:
- Journal of Industrial Hygiene and Toxicology 31: 142-145
Materials and methods
- Study type:
- health record from industry
- Endpoint addressed:
- acute toxicity: inhalation
Test material
- Reference substance name:
- Diisopropylamine
- EC Number:
- 203-558-5
- EC Name:
- Diisopropylamine
- Cas Number:
- 108-18-9
- Molecular formula:
- C6H15N
- IUPAC Name:
- bis(propan-2-yl)amine
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
Transient dimness of vision and, in a few instances, nausea and headaches were reported among men engaged in the distillation of diisopropylamine in a pilot plant operation. The visual distress occurred within 2 to 3 hours after exposure to unusually high concentrations of the vapour and persisted for one to 2 hours after the men went out into fresh air. The mean concentration of diisopropylamine in the pilot plant were said to be of the order of 100 to 200 mg/m3 (ca. 25-50 ppm), with 5-10-minute peaks of about 740 mg/m3 (ca. 180 ppm), occurring 2 or 3 times daily, near a drum into which diisopropylamine was being drained.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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