Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-558-5 | CAS number: 108-18-9
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
Diisopropylamine is irritative for the respiratory tract.
Additional information
The nasal irritation produced by Diisopropylamine was studied using male Swiss OF1mice. Groups of six mice each were exposed to concentrations of Diisopropylamine ranging from 88 to 351 ppm in air for 15 min to determine the concentration at which the respiratory rate was decreased by 50% (RD50) (Gagnaire et al., 1989 and 1993). The head of each mouse was isolated in an inhalation chamber, and the breathing frequency was measured with a pressure transducer before and during the exposure period. The RD50for Diisopropylamine was 161 ppm, and maximal effects were observed within 0.5 to 1 min.The authors also exposed groups of mice to 29 to 207 ppm of Diisopropylaminevia tracheal cannulation for 120 min. The concentration that caused a 50% decrease in respiratory rate via this route (RD50TC) was compared with the RD50 (161 ppm). The RD50TC was 102 ppm, and maximal effects were observed after 120 min of exposure. The authors noted that the RD50TC/RD50ratio was less than 1 (0.6), which indicated that Diisopropylamine primarily caused lower airway effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
