Registration Dossier
Registration Dossier
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EC number: 221-486-2 | CAS number: 3115-49-9
Specific investigations: other studies
Administrative data
- Endpoint:
- endocrine system modulation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 22.05.2012 - 25.05.2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: recent study conducted according to reliable in-house protocol
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: according to P. Sohoni and J.P. Sumpter (1998)
- Principles of method if other than guideline:
- The aim of the study was to determine the androgenic and antiandrogenic potential of (4-nonylphenoxy) acetic acid. The yeast cells used in the yeast androgen screening (YAS) assay have been stably transformed with genes for the human androgen receptor and the ß-galactosidase reporter gene. Andregenie as weil as antiandrogenic potentials of the test substances mediated by receptor binding or blocking can be determined using this assay, respectively.
- GLP compliance:
- no
- Type of method:
- in vitro
Test material
- Reference substance name:
- (4-nonylphenoxy)acetic acid
- EC Number:
- 221-486-2
- EC Name:
- (4-nonylphenoxy)acetic acid
- Cas Number:
- 3115-49-9
- Molecular formula:
- C17H26O3
- IUPAC Name:
- 2-(4-nonylphenoxy)acetic acid
- Details on test material:
- - Name of test material: (4-nonylphenoxy) acetic acid
- Physical state: Liquid, yellow to brown
- Analytical purity: >99%
- Storage condition of test material: Room temperature
Constituent 1
Administration / exposure
- Vehicle:
- DMSO
Results and discussion
- Details on results:
- ln this study, the test substance (4-nonylphenoxy) acetic acid showed no androgenic activity in comparison to dihydrotestosterone. ln this study, the test substance (4-nonylphenoxy) acetic acid showed clear antiandrogenic activity from about 10-5 mol/L in comparison to hydroxyflutamide. No cytotoxicity was observed.
Applicant's summary and conclusion
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