Registration Dossier
Registration Dossier
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EC number: 205-440-9 | CAS number: 140-90-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: The study was considered not reliable since the documentation of the study was insufficient for assessment. Especially, no details on the test substance composition was provided.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Sodium Ethyl Xanthate - Priority Exiting Chemical No. 5
- Author:
- National Industrial Chemicals Notification and Assessment Scheme (NICNAS)
- Year:
- 1 995
- Bibliographic source:
- Australian Government Publishing Service Canberra
Materials and methods
- Principles of method if other than guideline:
- Sodium ethyl xanthate was administered by occlusive application to the shaved abdomen of the rabbits either as 1 g/kg bw of the 100% dry material in a paste formed with water. The animals were observed for 12 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium O-ethyl dithiocarbonate
- EC Number:
- 205-440-9
- EC Name:
- Sodium O-ethyl dithiocarbonate
- Cas Number:
- 140-90-9
- Molecular formula:
- C3H6OS2.Na
- IUPAC Name:
- sodium (ethoxymethanethioyl)sulfanide
- Test material form:
- semi-solid (amorphous): gel
- Remarks:
- migrated information: paste
Constituent 1
Test animals
- Species:
- rabbit
Administration / exposure
- Type of coverage:
- occlusive
- Duration of exposure:
- 18 hrs
- Doses:
- 1 000 mg/kg bw
- No. of animals per sex per dose:
- Three rabbits
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- < 1 000 mg/kg bw
- Based on:
- test mat.
- Clinical signs:
- other: Surviving animal had moderate irritation with oedema and pigmentation of the skin.
- Gross pathology:
- Moderate amount of peritoneal fluid, visceral organs were normal.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Rabbit were exposed to sodium ethyl xanthate for 18 hours. The LD50 value was concluded to be < 1 000 mg/kg bw.
- Executive summary:
The study was considered not reliable since the documentation of the study was insufficient for assessment. Especially, no details on the test substance was provided. Thus, this study is used as a weight of evidence in the hazard assessment.
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