Registration Dossier
Registration Dossier
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EC number: 918-973-3 | CAS number: 1174522-45-2
Endpoint summary
Administrative data
Description of key information
All reliable studies on skin and eye irritation for C14-20 Aliphatics (≤2% aromatic) show no or slight irritation effects on rabbit skin and eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Fourteen reliable studies were available for skin irritation, dealing with the toxicity of different samples of C14-20 Aliphatics (≤2% aromatic). All studies were conducted similarly or according to OECD guideline 404. All studies show no or slight irritation effects on rabbits' skin. One reliable study was performed with human volunteers exposed to isohexadecane and isoeicosane for 24 h in occlusive conditions. Only slight signs of irritation lead to the conclusion that test substances were not skin irritant.
Nine studies were available for eye irritation, dealing with the toxicity of different samples of C14-20 Aliphatics (≤2% aromatic). All studies were conducted similarly or according to OECD guideline 405. All studies show no or slight irritation effects on rabbits' eyes.
Justification for classification or non-classification
As all reliable studies show no irritation effect or irritation effects slight enough not to classify the test materials, substances of the category do not need to be classified as irritant for skin and eye according to the criteria of Annex VI of Directive 67/548/EEC and CLP Regulation 1272/2008.
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