Registration Dossier
Registration Dossier
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EC number: 212-786-4 | CAS number: 869-24-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- EC50 for microorganisms:
- 220 mg/L
Additional information
The inhibitory effect of P5524 (which contains 99.9% DEC) to activated domestic sludge was determined in a static GLP compliant test according to OECD 209 (Bell 1995). The test was started with a Control (0), 10, 22, 46, 100, and 220 mg test item/L and a reference substance (3,5-dichlorophenol). Dose verification was not performed. two control replicates were set up. For each test concentration 1 replicate was set up. The test solutions were incubated for 3 hours. After 3 hours of exposure, 8, 16, (66), 38 and 46 % inhibition were recorded at, 10, 22, (46), 100, and 220 mg test item/L, respectively. The inhibition value for 46 mg/L was considered to be an outlier due to technical failure.The corresponding 3 h IC20 and IC 50 values are 33 and > 220 mg test item/L.
The test with the reference substance was within the accepted range of 5-30 mg/L.
This study was performed according to international guidelines and under GLP and fulfilled the validity criteria. Correct dosing was verified. Therefore, this study was considered to be Klimisch 1 study.
The obtained results are considered as relevant for the risk assessment.
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