Registration Dossier
Registration Dossier
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EC number: 212-786-4 | CAS number: 869-24-9
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 14 mg/L
Additional information
The acute toxicity of P5524 (which contains 99.9% DEC) to Daphnia magna was determined in a static GLP compliant test (Bell 1996). The test was performed according to guidelines OECD 201 and EU C.2. The test was started with a Control (0), 1.0, 2.2, 4.6, 10, 22, 46, and 100 mg test item/L. Dose verification at hour 0 confirmed that the test solutions were correctly dosed (recoveries of the biologically relevant concentrations > 80%. For each test concentration and the control, 2 replicates with 10 daphinds each were set up in 200 mL test solution (glass vessels). The test was performed in a 16:8 h light dark cycle. The concentrations were reported as nominal concentrations. After 48 hours of exposure, 0, 0, 0, 0, 5, 100, 100 and 100 % of the daphnids were immobilized at Control, 1.0, 2.2, 4.6, 10, 22, 46, and 100 mg test item/L. The corresponding 48 h EC50 value is 14 mg test item/L.
This study was performed according to international guidelines and under GLP and fulfilled the validity criteria. Correct dosing was verified. Therefore, this study was considered to be Klimisch 1 study.
The obtained results are considered as relevant for the risk assessment.
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