Registration Dossier
Registration Dossier
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EC number: 204-101-2 | CAS number: 115-70-8
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Patch testing with components of water-based metalworking fluids.
- Author:
- Greier, J. et al.
- Year:
- 2 003
- Bibliographic source:
- Contact Dermatitis 49, 85-90.
Materials and methods
- Study type:
- clinical case study
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-amino-2-ethylpropanediol
- EC Number:
- 204-101-2
- EC Name:
- 2-amino-2-ethylpropanediol
- Cas Number:
- 115-70-8
- Molecular formula:
- C5H13NO2
- IUPAC Name:
- 2-amino-2-ethylpropane-1,3-diol
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- A clinical trial of 233 patients with present or past occupational to metalworking fluids (MWF).
- Ethical approval:
- not specified
- Route of exposure:
- dermal
- Reason of exposure:
- intentional, occupational
Results and discussion
- Results of examinations:
- Only 1 patient reacted positively to AEPD.
Applicant's summary and conclusion
- Conclusions:
- Only 1 patient reacted positively to AEPD. The importance of AEPD as a MWF allergen still remains to be established.
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