Undec-10-enal

Adsorption / desorption

Link to relevant study record(s)

Reference

Endpoint:

adsorption / desorption: screening

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))

Principles of method if other than guideline:

Adsorption coefficient of test chemical was determined by using HPLC method.

GLP compliance:

no

Type of method:

HPLC estimation method

Media:

soil/sewage sludge

Radiolabelling:

no

Test temperature:

25°C

Details on study design: HPLC method:

HPLC Procedure:
The solutions of the test substance and reference substances were prepared in solvent mentioned in 4.3. Each of the reference substance and test substance were analysed by HPLC at 210 nm. After equilibration of the HPLC system, Urea was injected first, the reference substances were injected in duplicate, followed by the test chemical solution in duplicate. Reference substances were injected again after test sample, no change in retention time of reference substances was observed. Retention time tR were measured, averaged and the decimal logarithms of the capacity factors k were calculated. The graph was plotted between log Koc versus log k(table 3).The linear regression parameter of the relationship log Koc vs log k were also calculated from the data obtained with calibration samples and therewith, log Koc of the test substance was determined from its measured capacity factor.

Operating Conditions:
HPLC Model No. : Agilent Technologies,1260 Infinity
Flow Rate : 1.0ml/min
Column : ZORBAX Eclipse Plus C18, 4.6×100mm, 3.5 μm
Mobile phase : Methanol: water (3:1)
Temperature : 25°C
Detector : Diode Array Detector @210nm
Injector : Autosampler
Injector volume : 10μl
Data Acquisition software : ChemStationOpen lab Control Panel

Analytical monitoring:

not specified

Key result

Sample No.:

#1

Type:

log Koc

Value:

4.672 dimensionless

Temp.:

25 °C

Remarks on result:

other: other details not specified

Details on results (HPLC method):

The Adsorption coefficient (KOC) on soil and on sewage sludge of the test chemical was determined to be 4.672 ± 0.008 at 25°C

Transformation products:

not specified

Reference substance	Log Pow	tR1	tR2	tR3	MeantR± S.D.	k	Log k
Formamide	-	0.897	0.899	0.9	0.898±0.001	-	-
2,3 Dichloroaniline	2.8	1.823	1.826	-	1.824± 0.002	1.031	0.013
Benzophenone	3.2	2.448	2.393	-	2.420 ±0.038	1.695	0.229
1, 4 Dichlorobenzene	3.4	3.447	3.497	-	3.472 ± 0.035	2.866	0.457
Naphthalene	3.6	3.263	3.278	-	3.270 ± 0.010	2.641	0.421
Benzyl benzoate	4.0	4.047	4.014	-	4.030 ± 0.023	3.488	0.542
1 ,2 ,4 Trichlorobenzene	4.2	5.617	5.609	-	5.613 ± 0.005	5.250	0.720
N butylbenzene	4.6	7.963	7.966	-	7.964 ± 0.002	7.869	0.895
2 ,6 Diphenylpyridine	4.9	6.987	7.005	-	6.996 ± 0.012	6.790	0.831

Test substance		k	Log k	Log Pow by Generalized Calibration Graph	Mean of Log Pow± S.D.
tR1	7.644	7.512	0.875	4.666	4.672 ± 0.008
tR2	7.722	7.599	0.880	4.678

Validity criteria fulfilled:

yes

Conclusions:

The Adsorption Coefficient of test substance was determined as per the HPLC method (OECD Guideline-121). The Log Koc value was determined to be 4.672 ± 0.008 at 25°C. Thus based on the result it is concluded that the test substance has a very strong sorption to soil and sediment and therefore has negligible migration potential to ground water.

Executive summary:

The adsorption coefficient Koc in soil and in sewage sludge of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 121 for testing of Chemicals. The solutions of the test substance and reference substances were prepared in appropriate solvents. A test item solution was prepared by accurately weighing 50 mg of test item and diluted with mobile phase up to 100ml. Thus, the test solution concentration was 500 mg/l. The pH of test substance was 6.19.

Each of the reference substance and test substance were analysed by HPLC at 210 nm. After equilibration of the HPLC system, Urea was injected first, the reference substances were injected in duplicate, followed by the test chemical solution in duplicate. Reference substances were injected again after test sample, no change in retention time of reference substances was observed. Retention time tR were measured, averaged and the decimal logarithms of the capacity factors k were calculated. The graph was plotted between log Koc versus log k(Annex - 2).The linear regression parameter of the relationship log Koc vs log k were also calculated from the data obtained with calibration samples and therewith, log Koc of the test substance was determined from its measured capacity factor. The reference substances 2, 3 Dichloroaniline,Benzophenone,1, 4 Dichlorobenzene, Naphthalene, Benzyl benzoate, 1, 2, 4 Trichlorobenzene, N butylbenzene, 2, 6 Diphenylpyridine having Pow value ranging from 2.8 to 4.9

The Log Koc value of test chemical was determined to be 4.672 ± 0.008 dimensionless at 25°C.This log Koc value indicates that the substance has a very strong sorption to soil and sediment and therefore has negligible migration potential to ground water.

Description of key information

The Adsorption Coefficient of test substance was determined as per the HPLC method (OECD Guideline-121). The Log Koc value was determined to be 4.672 ± 0.008 at 25°C. Thus based on the result it is concluded that the test substance has a very strong  sorption to soil and sediment and therefore has negligible migration potential to ground water.

Key value for chemical safety assessment

Koc at 20 °C:

46 989

Additional information

The adsorption coefficient Koc in soil and in sewage sludge of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 121 for testing of Chemicals. The solutions of the test substance and reference substances were prepared in appropriate solvents.A test item solution was prepared by accurately weighing 50 mg of test item and diluted with mobile phase up to 100ml. Thus, the test solution concentration was 500 mg/l. The pH of test substance was 6.19.

Each of the reference substance and test substance were analysed by HPLC at 210 nm. After equilibration of the HPLC system, Urea was injected first, the reference substances were injected in duplicate, followed by the test chemical solution in duplicate. Reference substances were injected again after test sample, no change in retention time of reference substances was observed. Retention time tR were measured, averaged and the decimal logarithms of the capacity factors k were calculated. The graph was plotted between log Koc versus log k(Annex - 2).The linear regression parameter of the relationship log Koc vs log k were also calculated from the data obtained with calibration samples and therewith, log Koc of the test substance was determined from its measured capacity factor. The reference substances2, 3 Dichloroaniline,Benzophenone,1, 4 Dichlorobenzene, Naphthalene, Benzyl benzoate, 1, 2, 4 Trichlorobenzene, N butylbenzene, 2, 6 Diphenylpyridine having Pow value ranging from 2.8 to 4.9

The Log Koc value of test chemical was determined to be4.672 ± 0.008dimensionless at 25°C.This log Koc value indicates that the substance has a very strong sorption to soil and sediment and therefore has negligible migration potential to ground water.

[LogKoc: 4.672]