Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Registrant have not seen the actual study report, but dataholder is reliable

Data source

Reference
Reference Type:
other: email correspondence with dataholder/owner
Title:
No information

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 406 (Skin Sensitisation)
Deviations:
not specified
GLP compliance:
not specified
Type of study:
guinea pig maximisation test

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methanesulfonyl-5-(trifluoromethyl)-1,3,4-thiadiazole
EC Number:
809-978-0
Cas Number:
27603-25-4
Molecular formula:
C4H3F3N2O2S2
IUPAC Name:
2-methanesulfonyl-5-(trifluoromethyl)-1,3,4-thiadiazole
Test material form:
not specified

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
male

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
other: Intradermal and topical
Vehicle:
propylene glycol
Concentration / amount:
5 % (intradermal) and 6 % (topical) induction, 1 % and 0.5 % in challenge
Challengeopen allclose all
Route:
other: not known but likely intradermal and topical
Vehicle:
propylene glycol
Concentration / amount:
5 % (intradermal) and 6 % (topical) induction, 1 % and 0.5 % in challenge
Positive control substance(s):
not specified

Results and discussion

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance has distinct skin sensisation potential under the test conditions of the maximization test