Registration Dossier
Registration Dossier
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EC number: 203-518-7 | CAS number: 107-75-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable report which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Internal BASF method
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 7-hydroxycitronellal
- EC Number:
- 203-518-7
- EC Name:
- 7-hydroxycitronellal
- Cas Number:
- 107-75-5
- Molecular formula:
- C10H20O2
- IUPAC Name:
- 7-hydroxy-3,7-dimethyloctanal
- Details on test material:
- - Name of test material (as cited in study report): Hydroxycitronellal (HCA); 3.7-Dimethyl-7-hydroxyoctanol-1
- Physical state: liquid
- Purity: approx. 99%
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean 25.5 g (male), 22.3 g (female)
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- - Concentration: 4 - 30%
- Doses:
- 200, 250, 320, 400, 500, 640, 800 ccm/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: prior to study begin
- Necropsy of survivors performed: yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 504 mL/kg bw
- 95% CL:
- 441 - 576
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 517 mL/kg bw
- 95% CL:
- 407 - 656
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 486 mL/kg bw
- 95% CL:
- 413 - 572
- Mortality:
- 800 ccm/kg bw: 4/20 within 24 h; 6/20 within 48 h; 16/20 within 7 days
640 ccm/kg bw: 1/20 within 24 h; 5/20 within 48 h; 12/20 within 7 days; 13/20 within 14 days
500 ccm/kg bw: 2/20 within 24 h; 5/20 within 48 h; 9/20 within 7 days
400 ccm/kg bw: 3/20 within 48 h; 7/20 within 7 days
320 ccm/kg bw: 3/20 within 24 h; 4/20 within 48 h; 6/20 within 7 days; 7/20 within 14 days
250 ccm/kg bw: 1/20 within 24 h - Clinical signs:
- accelerated respiration, atonia, apathy, crusted eyes; 7 - 10 days after application without abnormal findings
- Gross pathology:
- splenomegaly, general passive hyperemia, intestinal atony; liver: clay-colored to gray
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
