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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Title:
Final report on the safety assessment of benzophenones-1, -3, -4, -5, -9, and -11
Author:
Anonymous
Year:
1983
Bibliographic source:
Journal of the American College of Toxicology, Volume 2, Number 5 (1983), page 35-77

Materials and methods

Test guideline
Guideline:
other: Shelanski RIPT
GLP compliance:
not specified
Type of study:
other: human patch test

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4-dihydroxybenzophenone
EC Number:
205-029-4
EC Name:
2,4-dihydroxybenzophenone
Cas Number:
131-56-6
Molecular formula:
C13H10O3
IUPAC Name:
4-benzoylbenzene-1,3-diol

In vivo test system

Test animals

Species:
human

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Vehicle:
other: butyl carbitol
Concentration / amount:
1%
Challengeopen allclose all
Vehicle:
other: butyl carbitol
Concentration / amount:
1%
No. of animals per dose:
100

Study design: in vivo (LLNA)

Vehicle:
acetone/olive oil (4:1 v/v)
Concentration:
25 microliter 0% (vehicle control), 1%, 10%, 25%, 50%
No. of animals per dose:
5
Positive control substance(s):
hexyl cinnamic aldehyde (CAS No 101-86-0)

Results and discussion

In vivo (non-LLNA)

Results
Reading:
other: no data
Group:
test chemical
Dose level:
1% in butyl carbitol
No. with + reactions:
0
Total no. in group:
100
Remarks on result:
other: Reading: other: no data. Group: test group. Dose level: 1% in butyl carbitol. No with. + reactions: 0.0. Total no. in groups: 100.0.

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU