Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 300-326-6 | CAS number: 93925-25-8
Neurotoxicity
Administrative data
Description of key information
No indication for neurotoxicity
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on neurotoxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on neurotoxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No experimental data from a neurotoxicity study are available. This endpoint is not a requirement in the relevant tonnage band of the submission item according to the REACH legislation. The submission item was checked for signs of neurotoxicity in the OECD TG 407 (2008) subacute repeated dose toxicity study of Dunster & Watson (2012, Harlan Report no. 41103273). To this end all test animals underwent neurobehavioural examination during week 4. The observations were carried out from approximately 2 h after dosing on each occasion. The battery of functions tested comprised behavioural assessments, functional performance tests and sensory reactivity. In summary no differences between treated and control animals were observed or were considered not to be indicative of toxicity. Due to this experimental result, the lack of chemical structure elements associated with neurotoxicity and the absence of critical information from structurally similar compounds or handling experience the submission item can be considered non-neurotoxic.
Justification for classification or non-classification
Based on the available data, the submission item is not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
