Phosphonic acid, mixed C12-20-alkyl and C14-18-unsatd. alkyl derivs.

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Between 17 October 2011 and 25 October 2011.

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Valid and conclusive guideline study under GLP

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

Commission Regulation (EC) No 440/2008 of 30 May 2008

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

Department of Health of Government of the U.K., inspection 19-21 July 2011

Type of method:

effusion method: vapour pressure balance

Temp.:

25 °C

Vapour pressure:

0 Pa

Remarks on result:

other: Mean of 9 measurements between 50 to 60 °C

Transition / decomposition:

no

Table 1: Summary of results

Run	Log Vp at 25 ºC [Pa]	Slope ± Standard deviation	Intercept ± Standard deviation
2	-3.170	-4494.231±132.693	1 1.904±0.404
3	-3.297	-4772.984±169.001	12.712±0.515
4	-3.373	-4896.609±190.543	13.050±0.581
5	-3.515	-5302.897±171.244	14.271±0.522
6	-3.427	-4991.940±141.453	13.316±0.431
7	-3.424	-5060.034±156.595	13.547±0.477
8	-3.282	-4605.359±446.656	12.165±1.361
9	-3.207	-4376.681±496.267	1 1.472±1.51 3
10	-3.599	-551 3.707±261 .I36	14.894±0.796
Mean	-3.366

A total of ten runs were completed for the main sequence. Equilibrium with regard to vapour pressure was assessed to have been reached over the final nine runs. Thus the final nine runs have been used to calculate the definitive vapour pressure value for the test item.

The test item did not change in appearance under the conditions used in the determination.

Conclusions:

Vapour pressure 0.00043 Pa at 25 ºC (irrelevantly low volatilization)

Executive summary:

The vapour pressure of the test item was determined in a GLP-compliant study using the effusion method (vapour pressure balance) according to the EU A.4 (2008) protocol. The experiment is deemed valid, conclusive and thus suitable for assessment without restrictions.

A sequence of runs was started after a sample of test item had been under vacuum for approximately 22¾ h. Temperature and pressure readings were taken between 50 and 60 ºC with a 1 h dwell at 50 ºC between runs. Linear regression analysis was used to conclude on the vapour pressure at 25 °C. Nine of the ten runs were evaluable as equilibration with regard to the vapour pressure was not reached in the first run. No decomposition was observed.

In conclusion the vapour pressure was found to be 0.00043 Pa at 25 ºC, which indicates irrelevantly low volatilization.

Description of key information

Irrelevantly low volatilization (EU Method A.4)

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

25 °C

Additional information

The vapour pressure was determined in a GLP-compliant study (Tremain & Atwal 2011, Harlan Report no. 41103264) using the effusion method (vapour pressure balance) according to the EU A.4 (2008) protocol. The experiment is deemed valid, conclusive and thus suitable for assessment without restrictions.

Measurements were made at several temperatures from 50 to 60 °C and linear regression analysis was used to conclude on the vapour pressure at 25 °C. No decomposition was observed.