Registration Dossier
Registration Dossier
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EC number: 203-581-0 | CAS number: 108-42-9
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Remarks:
- in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- ZVG No : 18790
- Author:
- IFA (GESTIS)
- Year:
- 2 011
- Bibliographic source:
- GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften):DFG: Toxikologisch-arbeitsmedizinische Begründungen von MAK-Werten; Verlag Chemie
Materials and methods
- Principles of method if other than guideline:
- The substance 3-chloroaniline showed skin sensitizing action in a valid maximization test on guinea pigs.
- GLP compliance:
- not specified
- Justification for non-LLNA method:
- not specified
Test material
- Reference substance name:
- 3-chloroaniline
- EC Number:
- 203-581-0
- EC Name:
- 3-chloroaniline
- Cas Number:
- 108-42-9
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 3-chloroaniline
- Details on test material:
- - Name of test material : 3-chloroaniline
- Substance type: Organic
- Physical state: Liquid
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: not specified
- Group:
- test chemical
- Remarks on result:
- positive indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance 3-chloroaniline showed skin sensitizing action in a valid maximization test on guinea pigs.
- Executive summary:
The substance 3-chloroaniline showed skin sensitizing action in a valid maximization test on guinea pigs.
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