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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
other: Authoritative data base
Title:
ZVG No: 18790
Author:
IFA (GESTIS)
Year:
2011
Bibliographic source:
GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
3-chloroaniline
EC Number:
203-581-0
EC Name:
3-chloroaniline
Cas Number:
108-42-9
Molecular formula:
C6H6ClN
IUPAC Name:
3-chloroaniline
Details on test material:
- Name of test material (as cited in study report):3-Chloroaniline
- Molecular formula:C6H6ClN
- Molecular weight:127.57
- Substance type:Organic
- Physical state:Liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
not specified
Controls:
not specified

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
conjunctivae score
Basis:
mean
Reversibility:
fully reversible
Remarks on result:
other: 3-Chloroaniline caused slight to moderate irritation to the conjunctiva but this was completely reversible; 3-Chloroaniline was therefore judged to be slightly to moderately irritating to the eyes.
Irritation parameter:
cornea opacity score
Basis:
mean
Reversibility:
fully reversible
Remarks on result:
other: 3-Chloroaniline caused slight to moderate irritation to the cornea but this was completely reversible; 3-Chloroaniline was therefore judged to be slightly to moderately irritating to the eyes.

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In a standardized test on rabbits' eyes (according to OECD guideline 405), 3-Chloroaniline caused slight to moderate irritation to the conjunctiva and cornea but this was completely reversible; 3-Chloroaniline was therefore judged to be slightly to moderately irritating to the eyes.
Executive summary:

In a standardized test on rabbits' eyes (according to OECD guideline 405), 3-Chloroaniline caused slight to moderate irritation to the conjunctiva and cornea but this was completely reversible; 3-Chloroaniline was therefore judged to be slightly to moderately irritating to the eyes.