Registration Dossier
Registration Dossier
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EC number: 203-581-0 | CAS number: 108-42-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- other: study report
- Title:
- Skin Irritation Test
- Author:
- CERI
- Year:
- 2 001
- Bibliographic source:
- CERI Hazard Data 2000-35 (2001)
Materials and methods
- Principles of method if other than guideline:
- Performed in accordance with OECD Test Guideline
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-chloroaniline
- EC Number:
- 203-581-0
- EC Name:
- 3-chloroaniline
- Cas Number:
- 108-42-9
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 3-chloroaniline
- Details on test material:
- - Name of test material (as cited in study report):3-chloroaniline
- Molecular formula:C6H6ClN
- Molecular weight:127.57
- Substance type:Organic
- Physical state:Liquid
Constituent 1
Test animals
- Species:
- other: no data
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- 24 and 48 hours
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 and 48 hours
- Reversibility:
- fully reversible
- Remarks:
- by 72 hours
- Remarks on result:
- other: The substance is thus considered "mildly irritating".
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 and 48 hours
- Reversibility:
- fully reversible
- Remarks:
- by 72 hours
- Remarks on result:
- other: The substance is thus considered "mildly irritating."
Applicant's summary and conclusion
- Interpretation of results:
- other: mild irritant
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Skin irritation tests performed in accordance with OECD Test Guideline: "Mild erythema and edema were induced at 24 and 48 hours, with recovery observed by 72 hours." The substance 3-chloroaniline is thus considered "mildly irritating."
- Executive summary:
Skin irritation tests performed in accordance with OECD Test Guideline: "Mild erythema and edema were induced at 24 and 48 hours, with recovery observed by 72 hours." The substance 3-chloroaniline is thus considered "mildly irritating."
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