Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-581-0 | CAS number: 108-42-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Acute toxicity : inhalation data for 108-42-9
- Author:
- Izmerov, N.F., et al.
- Year:
- 1 982
- Bibliographic source:
- "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 , 34,1982
- Reference Type:
- review article or handbook
- Title:
- DPIM : CEH675
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 007
- Bibliographic source:
- SAX (Sax's Handbook of Dangerous Industrial Materials):-Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al., Moscow.: ,USSR,Centre of International Projects, GKNT, 1982, 34.
- Reference Type:
- other: Authoritative data base
- Title:
- HSDB Number : 2046
- Author:
- Lewis, R.J.
- Year:
- 2 011
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC:Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996.,p.728
Materials and methods
- Principles of method if other than guideline:
- The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to mouse by the inhalative route.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3-chloroaniline
- EC Number:
- 203-581-0
- EC Name:
- 3-chloroaniline
- Cas Number:
- 108-42-9
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 3-chloroaniline
- Details on test material:
- - Name of test material (as cited in study report):3-chloroaniline
- Molecular formula:C6H6ClN
- Molecular weight:127.57
- Substance type:Organic
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 550 other: mg/m3
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: LC50=550 mg/m3,when converted into mg/L it is equivalent to 0.55 mg/L.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The lethal concentration (LC50) of 3 -Chloroaniline in mouse by the inhalative route was found to be 550 mg/m3. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the inhalative route in category 3.
- Executive summary:
The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to mouse by the inhalative route.The mouse were given the test substance by the inhalative route at a dose concentration of 550 mg/m3 of 3-chloroaniline.The lethal concentration (LC50) of 3 -Chloroaniline in mouse was found to be 550 mg/m3. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the inhalative route in category 3.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
