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EC number: 203-581-0 | CAS number: 108-42-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute toxicity : oral data for 108-42-9
- Year:
- 1 966
- Bibliographic source:
- Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 31(12),6,1966
- Reference Type:
- review article or handbook
- Title:
- DOSE doc no. : C155
- Author:
- RSC Publishing
- Year:
- 2 011
- Bibliographic source:
- Dictionary of Substances and their effects (DOSE):-Gig. Sanit. 1966, 31(2), 6.
- Reference Type:
- review article or handbook
- Title:
- DPIM : CEH675
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 007
- Bibliographic source:
- SAX (Sax's Handbook of Dangerous Industrial Materials):-GISAAA Gigiena i Sanitariya. 31(12) (1966), 6.
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : BX0350000
- Author:
- RTECS database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances):Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 31(12),6,1966
- Reference Type:
- other: Authoritative data base
- Title:
- HSDB Number : 2046
- Author:
- HSDB database
- Year:
- 2 011
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC:Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996.,p.728
Materials and methods
- Principles of method if other than guideline:
- The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to rat by the oral route.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-chloroaniline
- EC Number:
- 203-581-0
- EC Name:
- 3-chloroaniline
- Cas Number:
- 108-42-9
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 3-chloroaniline
- Details on test material:
- - Name of test material (as cited in study report):3-chloroaniline
- Molecular formula:C6H6ClN
- Molecular weight:127.57
- Substance type:Organic
- Physical state:Liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 256 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral lethal dose (LD50) of 3 -Chloroaniline in rat was found to be 256 mg/kg of body weight. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the oral route in category 3.
- Executive summary:
The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to rat by the oral route. The rats were given the test substance by the oral route at a dose concentration of 256 mg/kg of 3-chloroaniline.The lethal dose (LD50) of 3 -Chloroaniline in rat was found to be 256 mg/kg of body weight. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the oral route in category 3.
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