Registration Dossier
Registration Dossier
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EC number: 204-436-4 | CAS number: 120-93-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
- Report date:
- 1958
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- The substance was applied (90% in water) in the form of a paste for 1, 5, 15 minutes or 20 hours to the rabbit skin on the back.
- GLP compliance:
- no
- Remarks:
- pre-GLP
Test material
- Reference substance name:
- 2-imidazolidone
- EC Number:
- 204-436-4
- EC Name:
- 2-imidazolidone
- Cas Number:
- 120-93-4
- Molecular formula:
- C3H6N2O
- IUPAC Name:
- 2-imidazolidone
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- water
- Controls:
- other: untreated skin of same animal
- Amount / concentration applied:
- 90% in water in the form of a paste (amount not specified)
- Duration of treatment / exposure:
- 1 minute, 5 minutes, 15 minutes and 20 hours
- Observation period:
- 8 days
- Number of animals:
- 5 in total; substance has been applied on the skin of the back of all 5 animals
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: concentrated Lutrol and 50% lutrol
- Time after start of exposure: see duration of exposure; 1 minute, 5 minutes, 15 minutes and 20 hours
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Remarks:
- (1, 5 and 15 minutes of exposure)
- Basis:
- mean
- Time point:
- other: 24 hours and 8 days
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Remarks:
- (1, 5 and 15 minutes of exposure)
- Basis:
- mean
- Time point:
- other: 24 hours and 8 days
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- other: observations regarding skin irritation in case of 20 hours exposure
- Basis:
- mean
- Remarks on result:
- other: Slight erythema with individual hemorrhages at 24 hours. Circumscribed crusts (lentil-sized); fallen off at 8 days.
- Irritant / corrosive response data:
- The application for 1, 5 or 15 minutes on the back led to no findings within 8 days. After application for 20 hours, on the back, slight erythema was recorded with individual hemorrhages at 24 hours. Circumscribed crusts (lentil-sized; fallen off) were recorded at day 8 of the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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