2-imidazolidone

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given, acceptable for assessment.

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1964

Materials and methods

Type of study / information:

Fertility in insects

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The impact on fertility of insects was studied: test organisms were Drosophila melanogaster, house fly larvae and adults, large milkweed bug, corn earworm, and cucumber beetle among others. In general, the test substance was applied via the feed media.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-imidazolidone

EC Number:

204-436-4

EC Name:

2-imidazolidone

Cas Number:

120-93-4

Molecular formula:

C3H6N2O

IUPAC Name:

2-imidazolidone

Test material form:

solid

Results and discussion

Any other information on results incl. tables

The LOEL was about 50 ppm for drosophila and in a similar range for house flies. Surviving animals often exhibited morphological abnormalities on adult emergence though pupal development appeared outwardly normal. Mating of adults emerging from sublethal treatment resulted in normal development of second-generation adults of drosophila. This indicates that 2-Imidazolidinone is not a typical sterilant for this species, but rather an inhibitor of drosophila pupal development. On the other hand, 2-Imidazolidinone proved to be a sterilant in female house flies by preventing oviposition. In the milkweed bug, both sexes are rendered sterile on treatment of either young adults or last-instar nymphs.