Registration Dossier
Registration Dossier
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EC number: 622-542-2 | CAS number: 3891-98-3
Water solubility
Administrative data
Link to relevant study record(s)
Description of key information
Water solubility was investigated using a slow-stir method (Letinski et al., 2016) combined with SPME and GC-MS analysis. This is a more reliable and accurate method for the determination of the water solubility of poorly soluble hydrocarbons. The measured water solubility was 0.25 µg/L, which is supported by QSAR predicted water solubility values in the range 1.3 and 4.4 µg/L.
Key value for chemical safety assessment
- Water solubility:
- 0.25 µg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of Farnesane was tested experimentally as part of the ecotoxicity studies (Wildlife International 2012). In these ecotoxicity studies, acetone was used as the solvent because farnesane was known to be highly insoluble; solvents are used in eco toxicity studies to allow tests of the possible toxicity of a substance that is not readily soluble in water. The result of such a test provides an indication of the possible toxicity of the substance if it were able to dissolve and achieve a certain concentration. However, these are not naturally occurring conditions and hence water solubility and exposure are overestimated. Similarly, if a solubility test is conducted using a solvent the results are not indicative of the true solubility of the substance. Therefore, the water solubility results obtained from the ecotoxicity studies do not reflect the true water solubility of farnesane.
The slow-stir method, combined with SPME and GC-MS analysis used by Letinski et al. (2016) is considered a more reliable and accurate method for determination of the true water solubility of poorly soluble hydrocarbons. The measured water solubility was 0.25 µg/L, which is supported by QSAR predicted water solubility values in the range 1.3 and 4.4 µg/L. Farnesane is therefore considered essentially insoluble in water.
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