Registration Dossier
Registration Dossier
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EC number: 606-712-3 | CAS number: 211450-54-3
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The three estimations with BCFBAF v3.01 calculate an average level of BCF values of Fatty acids, C16 -18 and C18 -unsatd., Me esters, epoxidized, reaction products with ethylene glycol; Mono-, Di, and Tri-Adduct:
- Mono-Adduct of Fatty acids, C16 -18 and C18 -unsatd., Me esters, epoxidized, reaction products with ethylene glycol:
EPISuite v4.1/BCFBAFv3.01: A BCF value of 60.32 (log BCF = 1.780) was estimated on the basis of the log Kow of 5.29. Using the Arnot-Gobas method including biotransformation rates the BCF for the upper trophic level was estimated at 23.9 (log BCF = 1.378) (BASF, 2013).
- Di-Adduct of Fatty acids, C16 -18 and C18 -unsatd., Me esters, epoxidized, reaction products with ethylene glycol:
EPISuite v4.1/BCFBAFv3.01: A BCF value of 15.46 (log BCF = 1.189) was estimated on the basis of the log Kow of 11.77. Using the Arnot-Gobas method including biotransformation rates the BCF for the upper trophic level was estimated at 0.8945 (log BCF = -0.048) (BASF, 2013).
- Tri-Adduct of Fatty acids, C16 -18 and C18 -unsatd., Me esters, epoxidized, reaction products with ethylene glycol:
EPISuite v4.1/BCFBAFv3.01: A BCF value of 3.162 (log BCF = 0.500) was estimated on the basis of the log Kow of 18.26. Using the Arnot-Gobas method including biotransformation rates the BCF for the upper trophic level was estimated at 0.893 (log BCF = -0.049) (BASF, 2013).
CONCLUSIONS
BCF
values are in the range of 0.893 to 23.9 (Arnot-Gobas-method).
Considering mitigating factors like biotransformation, water solubility
and molecular size, there is low potential for bioaccumulation. In
addition, due to the low water solubility exposure of aquatic organisms
to significant amounts is unlikely. Therefore, unacceptable risks due to
possible bioaccumulation are not expected. Furthermore,
due to a molecular mass greater than 700, the test substance is not
readily taken up by fish, because of possible steric hindrance at
passage of gill membranes or cell membranes of respiratory organs
(Technical Guidance Document on Risk Assessment (TGD) Part 2 (2003),
Institute for Health and Consumer Protection, European Chemicals Bureau).In
addition, based on current knowledge, a calculated log Kow of 10 or
above is taken as an indicator of reduced bioconcentration. (Chapter
R.7C-Endpoint Specific Guidance; R7.10.3.4)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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