Registration Dossier
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EC number: 606-712-3 | CAS number: 211450-54-3
Endpoint summary
Administrative data
Description of key information
Additional information
Fatty acids, C16-18 and C18 unsatd., Me esters, epoxidized, reaction products with ethylene glycol (CAS-No. 211450-54-3) has a potential to bioaccumulate due to their physico-chemical properties (log Kow > 3).
Considering the calculated Bioaccumulation Estimates (EPISUITE, v4.10) the BCF values of the Mono-, Di- and the Tri-Adduct are between 23.9 L/kg to 0.893 l/kg (Arnot-Gobas method, upper trophic), the BAFvalues are between 23.9 and 0.893 (Arnot-Gobas method, upper trophic). The readily biodegradability, which makes exposure of the aquatic compartment unlikely, and no toxicity to fish (EC50 >100 mg/L), uptake into fish is expected to be hindered by the large molecular size (therefore a strong steric hindance for crossing biological membranes is indicated), no bioaccumulation is expected. If taken up by fish, these carboxylate ester-containing substances are expected to be readily metabolized and excreted. Sedimental and terrestrial bioaccumulation is considered to be not relevant as the substance is readily biodegradable.
In addition, based on current knowledge, a calculated log Kow of 10 or above (here the Fatty acids, C16 -18 and C18 unsatd., Me esters, epoxidized, reaction products with ethylene glycol, Di-Adduct has a log Kow of 11.77 and the Fatty acids, C16 -18 and C18 unsatd., Me esters, epoxidized, reaction products with ethylene glycol, Tri-Adduct has a log Kow of 18.26) is taken as an indicator of reduced bioconcentration. (Chapter R.7C-Endpoint Specific Guidance; R7.10.3.4). However, as the substance is readily biodegradable, no chronic exposure of aquatic organisms is expected. Due to the high molecular weight, a strong sterical hindrance for crossing biological membranes is indicated.
Based on all relevant data available for the assessment of the bioaccumulation potential, it can be concluded that Fatty acids,C16 -18 and C18 -unsatd., Me esters, epoxidized, reaction products with ethylene glycol has low potential for bioaccumulation and biomagnification via the food chain.
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