Registration Dossier
Registration Dossier
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EC number: 203-691-9 | CAS number: 109-65-9
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- Written assessment
- Type of information:
- other: Written assessment
- Adequacy of study:
- other information
- Study period:
- February 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Written assessment
- Justification for type of information:
- At the current level of registration, a written assessment is suitable.
Data source
Reference
- Reference Type:
- other: Written assessment
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
- Objective of study:
- other: Written assessment of ADME
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Written assessment based on available study data.
Test material
- Reference substance name:
- 1-bromobutane
- EC Number:
- 203-691-9
- EC Name:
- 1-bromobutane
- Cas Number:
- 109-65-9
- Molecular formula:
- C4H9Br
- IUPAC Name:
- 1-bromobutane
Constituent 1
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- See overall remarks below
- Details on distribution in tissues:
- See overall remarks below
- Details on excretion:
- See overall remarks below
Metabolite characterisation studies
- Details on metabolites:
- See overall remarks below
Bioaccessibility (or Bioavailability)
- Bioaccessibility (or Bioavailability) testing results:
- See overall remarks below
Applicant's summary and conclusion
- Conclusions:
- Based upon the data available, the substances are similar and follow a regular pattern of predicted properties as a result of that structural similarity. Therefore, the definition of a chemical category has been met, and read across is considered appropriate for the category of chemical. The substanceis analogous to the substance to be read across to, in terms of basic form. The metabolic data on the structural analogue corroborates the conclusion that the substance is not considered to be bioaccumulative.
- Executive summary:
Based upon the data available, the substances are similar and follow a regular pattern of predicted properties as a result of that structural similarity. Therefore, the definition of a chemical category has been met, and read across is considered appropriate for the category of chemical.The substanceis analogous to the substance to be read across to, in terms of basic form.The metabolic data on the structural analogue corroborates the conclusion that the substance is not considered to be bioaccumulative.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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