Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-224-9 | CAS number: 104-66-5
Toxicological information
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 26 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 75
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 1 952 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- default AF; clear NOAEL
- AF for differences in duration of exposure:
- 6
- Justification:
- default AF for sub-acute to chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- no difference in metabolic rate (inhalation)
- AF for other interspecies differences:
- 2.5
- Justification:
- remaining differences
- AF for intraspecies differences:
- 5
- Justification:
- default AF for workers
- AF for the quality of the whole database:
- 1
- Justification:
- default AF; GLP study
- AF for remaining uncertainties:
- 1
- Justification:
- default AF; no remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.33 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- default AF; clear NOAEL
- AF for differences in duration of exposure:
- 6
- Justification:
- default AF for sub-acute to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- differences in metabolic rate (rat/human)
- AF for other interspecies differences:
- 2.5
- Justification:
- default for remaining differences
- AF for intraspecies differences:
- 5
- Justification:
- default AF for workers
- AF for the quality of the whole database:
- 1
- Justification:
- default AF; GLP study
- AF for remaining uncertainties:
- 1
- Justification:
- default; no remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- insufficient hazard data available (further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- insufficient hazard data available (further information necessary)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 6.48 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 150
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 972 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- default AF; clear NOAEL
- AF for differences in duration of exposure:
- 6
- Justification:
- default AF for sub-acute to chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- no difference in metabolic rate (inhalation)
- AF for other interspecies differences:
- 2.5
- Justification:
- remaining differences
- AF for intraspecies differences:
- 10
- Justification:
- default AF for general population
- AF for the quality of the whole database:
- 1
- Justification:
- default AF; GLP study
- AF for remaining uncertainties:
- 1
- Justification:
- default AF; no remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.67 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- default AF; clear NOAEL
- AF for differences in duration of exposure:
- 6
- Justification:
- default AF for sub-acute to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- differences in metabolic rate (rat/human)
- AF for other interspecies differences:
- 2.5
- Justification:
- default for remaining differences
- AF for intraspecies differences:
- 10
- Justification:
- default AF for general population
- AF for the quality of the whole database:
- 1
- Justification:
- default AF; GLP study
- AF for remaining uncertainties:
- 1
- Justification:
- default; no remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- insufficient hazard data available (further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- insufficient hazard data available (further information necessary)
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.67 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- default AF; clear NOAEL
- AF for differences in duration of exposure:
- 6
- Justification:
- default AF for sub-acute to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- differences in metabolic rate (rat/human)
- AF for other interspecies differences:
- 2.5
- Justification:
- default for remaining differences
- AF for intraspecies differences:
- 10
- Justification:
- default AF for workers
- AF for the quality of the whole database:
- 1
- Justification:
- default AF; GLP study
- AF for remaining uncertainties:
- 1
- Justification:
- default; no remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
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