Registration Dossier
Registration Dossier
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EC number: 219-292-8 | CAS number: 2403-89-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
- Toxic effect type:
- dose-dependent
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 226 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The OECD toolbox v3.4 study for repeated dose according to TG422 (oral, rat, gavage, 45d) gave as NOEL result 226 mg/kg bw/day
In the same OECD TG422 protocol for the close analogue substance 2,2,4,4 -tetramethylpiperidin-4 -ol (EINECS 219 -291 -2), which is missing the methyl-group on the N, its OECD SIDS describes a LOAEL of 60 mg/kg based on ophthalmological signs. Other effects (mortality) only occurred at the highest dose level of 600 mg/kg/d. A NOAEL could not be identified.
Justification for classification or non-classification
At the found effect level of NOEL=226 mg/kg/d in this OECD TG422 study there is no requirement for classification.
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