Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1960

Materials and methods

Objective of study:
absorption
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Oxalonitrile
EC Number:
207-306-5
EC Name:
Oxalonitrile
Cas Number:
460-19-5
Molecular formula:
C2N2
IUPAC Name:
carbononitridic cyanide
Test material form:
gas
Specific details on test material used for the study:
ethanedinitrile 99.5 %
Radiolabelling:
no

Test animals

Species:
rabbit
Strain:
not specified
Remarks:
albino rabbit
Sex:
male

Administration / exposure

Route of administration:
inhalation: gas
Vehicle:
other: air
Duration and frequency of treatment / exposure:
8h
Doses / concentrations
Dose / conc.:
10 000 ppm
No. of animals per sex per dose / concentration:
4
Control animals:
yes

Results and discussion

Metabolite characterisation studies

Metabolites identified:
not measured

Applicant's summary and conclusion

Conclusions:
Inhalation
Absorption of ethanedinitrile occurs through lungs.

Dermal
Ethanedinitrile has no absorption through skin, exposure of 10,000 ppm (~ 21 g/m3) for eight hours, did not resulted any clinical observations or macroscopic effects on rabbit (McNerney and Schrenk 1960).
Executive summary:

Absorption of ethanedinitrile occurs through lungs. Ethanedinitrile has no absorption through skin, exposure of 10,000 ppm (~ 21 g/m3) for eight hours, did not resulted any clinical observations or macroscopic effects on rabbit.