Registration Dossier
Registration Dossier
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EC number: 231-810-4 | CAS number: 7747-35-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The ability of CS-1246 to induce dermal sensitization was examined in a Guinea Pig Maximization Test (Kreuzmann, J.J., 1989). Based on results of the induction/challenge CS-1246 was determined to be a dermal sensitizer in guinea pigs.
References:
Kreuzmann, J.J. (1989) Guinea Pig Maximization Test (Magnusson and Kligman Method). Hill Top Biolabs. The Dow Chemical Company Report No: DR-0365-7725-005. GLP, Unpublished
Migrated from Short description of key information:
Based on a positive result in the guinea pig maximization study, the substance is expected to be a dermal sensitizer.
Justification for classification or non-classification
The substance is classified as Xi R43 (May cause sensitization by skin contact) according to DSD and as as a Skin sensitizer Cat.1; H317 (May cause an allergic reaction) according to CLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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