Registration Dossier
Registration Dossier
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EC number: 806-919-0 | CAS number: 1356964-77-6
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The 96-h EbC50, ErC50 and EyC50 values were 6.3, >9.0 and 7.2 mg/L, respectively. The NOEC for all parameters was 1.1 mg/L.
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 1.1 mg/L
Additional information
In a study performed according to OECD TG 201 and EU Method C.3, Pseudokirchneriella subcapitata was exposed to five concentrations of the substance ranging from 0.12 to 9.0 mg/L based on geometric mean measured concentrations and evaluated for effects on area under the growth curve, growth rate and yield for 96 hours [Jacobs et al, 2014]. The 96-h EbC50, ErC50 and EyC50 values, based on area under the growth curve, growth rate and yield were 6.3, >9.0 and 7.2 mg/L, respectively. Based on evaluation of the statistical results and the concentration response pattern of the growth inhibitions on area under the growth curve, growth rate and yield, the NOEC for all parameters was determined to be 1.1 mg/L.
The results of this study are supported by the results from a study performed according to OECD test guideline 201 with the alga Pseudokirchneriella subcapitata using the read-across substance N,N-dimethyldecan-1 -amide, mixture with N,N-dimethyloctan-1 -amide (CAS No. 67359 -57 -3) [Anderson, 1993]. The test substance was applied directly (no vehicle was used) for 72h in a static freshwater system. Good agreement of nominal and measured concentrations was verified analytically. All validity criteria were met. The growth rate EC50 (72h) of the test substance was 16.06 mg/l, while the growth rate NOEC (72h) was 1.8 mg/L.
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