Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-236-5 | CAS number: 455-14-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Publication in Russian, a short summary was available in english. The study seems to be well described, and 2 species were tested. This data is cited in DOSE, Sax's.
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Khalepo
- Year:
- 1 968
- Bibliographic source:
- Toksikol. Nov. Prom. Khim. Veshchestv, 10, p : 131-140
Materials and methods
Test guideline
- Guideline:
- other: no data
- GLP compliance:
- no
- Test type:
- other: inhalation study, no more data
Test material
- Reference substance name:
- α,α,α-trifluoro-m-toluidine
- EC Number:
- 202-643-4
- EC Name:
- α,α,α-trifluoro-m-toluidine
- Cas Number:
- 98-16-8
- Molecular formula:
- C7H6F3N
- IUPAC Name:
- 3-(trifluoromethyl)aniline
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- other: rat and mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 220 +/- 40 g
ENVIRONMENTAL CONDITIONS:
- Temperature (°C): 28°C
No more data
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
No more data - Statistics:
- according to Litchfield & Wilcoxon, corrected by Pot
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 0.44 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: (0.40-0.49 mg/L) for rats
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 0.69 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: (0.60-0.79 mg/L) for mice
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP classification: Toxicity Category III
- Executive summary:
In an acute inhalation toxicity study (Khalepo, 1968), groups of rats and mice were exposed by inhalation route to meta-trifluoromethylaniline for 4 hours. Animals were observed for 2 weeks. LC50= 0.44 mg/L for rats and 0.69 mg/L for mice.
Meta-trifluoromethylaniline is classified as toxic T R23 by inhalation route, according to the EU classification criteria (67/548/EC directive).
It is classified acute category 3 (H331), according to CLP criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
