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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The study is not GLP compliant, no guidelines were strictely followed and only short documentation is available (publication).

Data source

Reference
Reference Type:
publication
Title:
The antiseptic value and toxicity of menthol isomers
Author:
Franck Wokes
Year:
1932
Bibliographic source:
Journal of Pharmacy and Pharmacology 5 (1932), pp. 233–244

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
L-menthol
EC Number:
218-690-9
EC Name:
L-menthol
Cas Number:
2216-51-5
IUPAC Name:
2-isopropyl-5-methylcyclohexanol
Details on test material:
none provided

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
olive oil
Doses:
Concentration of testing material in vehicle was between 10% and 20%.
2 to 4 mg/g bw of the solution was orally given to the mice.
No. of animals per sex per dose:
10 mice per dose
sex was not specified
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: several days
The mice were deprived of food several hours before gavage to ensure optimal absorption of l-menthol.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3.4 other: g/kg bw
Based on:
dissolved

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
The LD50 for L-menthol was found to be 3 g/kg bw in the study conditions.
L-menthol is then considered non toxic.