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Physical & Chemical properties

Partition coefficient

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
30 September 1998
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
4.3
Remarks on result:
other: pH and temp. not detailed in the study report
Type:
Pow
Partition coefficient:
19 953
Remarks on result:
other: pH and temp. not detailed in the study report
Details on results:
For calibration the retention times of a series of "neutral" substances with known n-octanol/water partition coefficients were measured and a calibration graph according to equation was established.

The n-octanol/water partition coefficient of the test substance T-9601 was derived from its retention time and the calibration graph.
Conclusions:
The objective of this study was the determination of the partition coefficient n-octanol/water of the test substance T-9601 according to guideline 92/69/EEC, appendix, A.8. The study was conducted in compliance with the Principles of Good Laboratory Practice(GLP).
The partition coefficient n-octanol/water of the test substance T-9601 has been determined according to the "HPLC method" as:

log Pow = 4.3
Pow = 19953

Description of key information

The log Pow of the Substance was determined to be 4.3.

Key value for chemical safety assessment

Log Kow (Log Pow):
4.3

Additional information

The partition coefficient of the test item was determined by the HPLC method according to the European Commission Regulations (EC) No. 440/2008, A.8. partition coefficient n-octanol/water.