Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: 2a: Data from international report and study was performed according to OECD guideline without detail documentation.

Data source

Reference
Reference Type:
review article or handbook
Title:
SIDS INITIAL ASSESSMENT PROFILE
Author:
OECD
Year:
2011
Bibliographic source:
UNEP publications
Report date:
2011

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
GLP compliance:
not specified
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
Thiophene
EC Number:
203-729-4
EC Name:
Thiophene
Cas Number:
110-02-1
Molecular formula:
C4H4S
IUPAC Name:
thiophene

Test animals

Species:
rat
Strain:
not specified
Sex:
female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
Lower test dose used in this study: 300 mg/kg bw
Highest test dose: 2000 mg/kg bw

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
not specified
Other findings:
At the lower test dose used in this study, 300 mg/kg bw, the rats showed drooping eyelids, salivation and soiled perineal region.
Additional effects seen at 2000 mg/kg bw included decreased locomotor activity, smudges around the mouth and nose, unkempt fur.
Macroscopic examination revealed no abnormal changes.

Applicant's summary and conclusion

Conclusions:
The oral LD50 has been reported as more than 2000 mg/kg bw in female rats (OECD n°423).