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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
column elution method
Water solubility:
1.26 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
6.6
Remarks on result:
other: pH given is the average of all determinations from both tests. Range 6.3-6.7 SU.
Details on results:
Six samples were analysed in the first run at 0.52 mL/min, and six in the second run at 0.26 mL/min. The quantification was performed by HPLC, and the water solubility of DMBPC at 20 °C was determined to be 1.26 mg/L (± 0.02 mg/L).
Conclusions:
The water solubility of the test material at 20 °C was determined to be 1.26 ± 0.02 mg/L.
Executive summary:

The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105 and EU Method A.6 under GLP conditions using the column elution method.

The flow rate was adjusted to approximately 30 mL/h (i.e. 0.52 mL/min) in the first experiment. The result obtained was confirmed by a second experiment using half the flow rate of the first experiment (approximately 0.26 mL/min).  The column eluate was sampled (six samples/experiment) in time intervals of at least 1 hour to determine the concentration of the test material. Total elution time was 96.5 hours. The quantification was performed by HPLC.

The water solubility of the test material at 20 °C was determined to be 1.26 ± 0.02 mg/L.

Description of key information

The water solubility was determined to be 1.26 mg/L at 20 °C and pH 6.6.

Key value for chemical safety assessment

Water solubility:
1.26 mg/L
at the temperature of:
20 °C

Additional information

The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105 and EU Method A.6 under GLP conditions using the column elution method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

The flow rate was adjusted to approximately 30 mL/h (i.e. 0.52 mL/min) in the first experiment. The result obtained was confirmed by a second experiment using half the flow rate of the first experiment (approximately 0.26 mL/min).  The column eluate was sampled (six samples/experiment) in time intervals of at least 1 hour to determine the concentration of the test material. Total elution time was 96.5 hours. The quantification was performed by HPLC.

The water solubility of the test material at 20 °C was determined to be 1.26 mg/L (± 0.02 mg/L).