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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1966
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data are given

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report date:
1966

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
not specified
Principles of method if other than guideline:
Method: BASF-test
- Exposure period was 1, 5, and 15 minutes.
- Occlusive instead of semi-occlusive dressing
- No scoring at 60 minutes, and at 48 and 72 hours is reported
- No observation up to 14 days after dosing is indicated (with respect to reversibility, etc).
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trimethylenediamine
EC Number:
203-702-7
EC Name:
Trimethylenediamine
Cas Number:
109-76-2
Molecular formula:
C3H10N2
IUPAC Name:
propane-1,3-diamine

Test animals

Species:
rabbit
Strain:
Vienna White

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
Not indicated.
Duration of treatment / exposure:
1, 5, 15 min
Observation period:
24h, 8 days
Number of animals:
2 per duration of exposure
Details on study design:
TEST SITE
- Area of exposure: 2.5 * 2.5 cm
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Yes (water, sometimes with mild detergent)
SCORING SYSTEM:
Recorded scores:
N++ or N+++: Full thickness necrosis

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: necrosis
Basis:
mean
Time point:
other: 24h
Remarks on result:
other: Strong necrosis in all test groups
Irritation parameter:
other: necrosis
Basis:
mean
Time point:
other: 8 days
Remarks on result:
other: Strong necrosis in 1 and 5 min exposure groups and very strong necrosis in 15 min exposure group

Applicant's summary and conclusion

Interpretation of results:
Category 1B (corrosive) based on GHS criteria