Registration Dossier
Registration Dossier
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EC number: 203-702-7 | CAS number: 109-76-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to aquatic algae.
Key value for chemical safety assessment
- EC50 for marine water algae:
- 299 mg/L
Additional information
The toxicity of trimethylenediamine (CAS 109-76-2) was tested in a growth inhibition test according to the German Industrial Standard DIN 38412, Part 9. The test species was Desmodesmus subspicatus. The test item was studied in two separate assays with either pH-adjusted or not pH-adjusted test solutions. The 72 -h ErC50 was determined to be 175 mg/L if the test solutions were not pH-adjusted (nominal; BASF AG 1990; Study no. 2/0489/89). After pH adjustment no effects were noted, the 72 -h NOErC and the ErC50 were greater than 500 mg/L (nominal; BASF AG 1990; Study No. 2/w498/89). The test item concentrations were not analytically verified, but are assumed to be stable.
In a study conducted according to ISO 10253 (Water quality - Marine Algal Growth Inhibition Test with Skeletonema costatum and Phaeodactylum tricornutum) the growth rate of Skeletonema costatum was inhibited by 50% at a concentration of trimethylenediamine of 299 mg/l after 72 hours (Eide-Haugmo, 2009, 2012).
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