Registration Dossier
Registration Dossier
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EC number: 214-275-1 | CAS number: 1119-34-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Waiving of experimental study. EC50 for algae was calculated to be ca. 26857 mg/L.
Key value for chemical safety assessment
Additional information
Data from a higher trophic level (fish and invertebrates) are available which lead to the conclusion that aquatic toxicity does not occur. In accordance with Annex XI No. 1.2 an experimental study is not conducted as there is sufficient weight of evidence from several independent sources of information leading to the assumption/conclusion that the substance does not cause aquatic toxicity to algae.
EC50 for algae was calculated to be ca. 26857 mg/L. Considering the fact that calculation models for aquatic toxicity to algae usually produce values which are conservative to unrealistic conservative, even the estimated high EC50 might not reflect actual toxicity to algae by L-arginine-HCl. Higher EC50 might be possible.
L-arginine-HCl is present as L-arginine under physiological conditions. L-arginine a is a naturally occuring amino acid which is omnipresent bin nature. It is a basic metabolit and building block of all living organisms and cells and is also a nutrient for algae.Thus significant toxicity to algae by L-arginine-HCl can be excluded.
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