Registration Dossier
Registration Dossier
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EC number: 204-438-5 | CAS number: 120-94-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1967-08-17 to 1967-08-28
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifially acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- only 7 days observation period
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-methylpyrrolidine
- EC Number:
- 204-438-5
- EC Name:
- 1-methylpyrrolidine
- Cas Number:
- 120-94-5
- Molecular formula:
- C5H11N
- IUPAC Name:
- 1-methylpyrrolidine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: US rats
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The test substance was administered in concentrations of 2, 4, 8 and 20% (V/V).
- Doses:
- 160, 200, 256, 320, 640, 1280 mg/kg
- No. of animals per sex per dose:
- 10 per dose level
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- ca. 280 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value: ca. 0.35 mL/kg; the LD50 value was calculated using a densitiy of 0.8003 g/mL (at 20 °C)
- Mortality:
- 160, 200 and 256 mg/kg: no deaths; 320: 8/10 after 7 days; 640 and 1280 mg/kg: 10/10 after 7 days
- Clinical signs:
- other: Dyspnea, spasms, abdominal and lateral position, cyanosis and apathy were observed.
- Gross pathology:
- Nothing abnormal detected.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
