Registration Dossier
Registration Dossier
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EC number: 200-543-5 | CAS number: 62-56-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Remarks:
- citation in the IPCS "Concise International Chemical Assessment Document" 49
Data source
Reference
- Reference Type:
- publication
- Title:
- Thiouracils and Thioureas - Comparison of the Absorption, Distribution, Destruction and Excretion
- Author:
- Williams, R.H. and Kay, G.A.
- Year:
- 1 947
- Bibliographic source:
- Arch Intern Med. 80 (1); 37-52
Materials and methods
- Objective of study:
- absorption
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- oral application of Thiourea with subsequent analysis of Thiourea content in urine and feces
- GLP compliance:
- no
Test material
- Reference substance name:
- Thiourea
- EC Number:
- 200-543-5
- EC Name:
- Thiourea
- Cas Number:
- 62-56-6
- Molecular formula:
- CH4N2S
- IUPAC Name:
- thiourea
- Test material form:
- solid
- Details on test material:
- carbon atom in thiourea was radiolabelled
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- other: human, rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- single exposure
Doses / concentrations
- Remarks:
- Doses / Concentrations:
a single oral dose of 28,57 mg Thiourea/kg bw (human)
5 mg administered intravenously (rat)
- No. of animals per sex per dose / concentration:
- no data
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- A singel oral dose of 28,57 mg thiourea/kg bw in humans was completely eliminated within 48h in urine; a peak concentration was measured within 30 min.
In rats administered 5 mg intravenously, 30% of thiourea was recovered from the carcasses after 3h, and only traces after 25h.
No thiourea was excreted in the stools
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: no bioaccumulation potential based on study results
Thiourea is rapidly absorbed form the GI tract and completely eliminated in the urine. - Executive summary:
A singel oral dose of 28,57 mg thiourea/kg bw in humans was completely eliminated within 48h in urine; a peak concentration was measured within 30 min. In rats administered 5 mg intravenously, 30% of thiourea was recovered from the carcasses after 3h, and only traces after 25h. No thiourea was excreted in the stools.
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